Endocrine Abstracts

Introduction: Surgical resection is currently considered the standard treatment for symptomatic insulinomas; however, its morbidity is high (>10%) and it is restricted to suitable candidates. In recent years, alternative minimally invasive therapies, such as endoscopic ultrasound (EUS)-guided ethanol ablation (EA), have emerged as new therapeutic options, especially for small lesions or poor surgical candidates. We report two cases of insulinoma ablated with EA.<p clas...

Introduction: Denosumab is a monoclonal antibody indicated in the treatment of postmenopausal osteoporosis. Hypocalcemia is a rare adverse effect.Case report: We present the case of a 58-year-old woman with a clinical history of bariatric surgery in 2001 and osteoporosis with multiple vertebral and hip fractures. Under treatment with Zinc sulphate, Vitamin A, 25-OH-vitamin D, calcium and iron. She came to the A&E for general malaise, generalized weak...

Metabolic syndrome (MetS) and type-2 diabetes (T2D) development is critically affected by the loss of phenotypic flexibility (i.e. the difficulty to cope with stressors to maintain metabolic homeostasis). Thus, it is essential to identify key modifiers of phenotypic plasticity that define individual susceptibility to develop T2D. Particularly, there is emerging evidence that alternative mRNA splicing is dysregulated under adverse metabolic-conditions, such as T2D, in several t...

Background: Prader-Willi syndrome (PWS) is a rare genetic disorder evolving morbid obesity and growth hormone deficiency (GHD). Testing GH-IGF1 axis is required before treatment with rhGH in adults with PWS (1). The most common used tests in these patients are GHRH+arginine (GHRH+a) and insulin tolerance test. There are no prospective data for glucagon test (GT) in comparison to GHRH+a in adults with PWS. Mechanism by which GT causes GH release remains unclear, glucagon-induce...

Introduction: Optimization of iodine intake aims to prevent the irreversible damage that iodine deficiency (ID) can cause in the central nervous system during its development, as well as thyroid disorders that can be induced by both ID and excessive micronutrient intake. The Spanish legal regulation stipulates that iodized salt (IS) must contain 60 mg of iodine per kg of salt (60 ppm), allowing a tolerance of ±15%. The aim of this study is to address the iodine content of...

Introduction: Most serum cortisol (SeC) is linked to cortisol binding globulin and albumin. When the synthesis of proteins is reduced or increased, SeC does not reflect the actual free cortisol (FC) (active fraction). Methods for FC analysis are very laborious and expensive, which makes difficult to use them as a routine laboratory tests. Salivary cortisol (SaC) mirrors the FC in serum, being its measurement easier and cheaper. The determination of SaC, instead of tot...

Introduction: Prader–Willi syndrome is a genetic disorder characterized by hypotonia, intellectual disabilities, obesity and behavioral disturbance. Patients present with several neuroendocrinological abnormalities, such as growth hormone deficiency, hypogonadotropic hypogonadism, and hyperphagia, as the result of possible involvement of the hypothalamo-hypophyseal system. Diffusion tensor imaging (DTI) is a noninvasive MRI technique capable of providing quantitative indi...

Background: Previous studies of association between maternal thyroid autoimmunity and adverse pregnancy outcomes have produced inconsistent results.Objective: To examine whether thyroid autoimmunity detected at first trimester screening is predictive of a range of adverse obstetric and fetal outcomes.Patients and methods: We studied 438 women with singleton pregnancies who underwent first trimester screening test between June and J...

Introduction: Obesity is characterized by a low-grade inflammatory state which has been directly related to the development of insulin resistance and diabetes. Circulating lipopolysaccharides (LPS) have been proposed as a triggering factor for this inflammation. Likewise, adipose tissue (AT) capacity for lipid handling and storage is also a key factor for the development of obesity-related metabolic disorders. Animal studies have shown that LPS are able to modify the expressio...

Materials and methods: We studied 30 MO patients with OSA without Continuous Positive Airway Pressure (CPAP) treatment, before and one year after surgery. All patients underwent overnight conventional polisomnography (CE-Series Compumedics, Victoria, Australia). Sleeve gastrectomy or Roux-en-Y gastric bypass were performed according to the local protocol. To asses AS, augmentation index adjusted for heart rate (IAx@75) was obtained by applanation tonometry (Sphygmocor&#17...